Title : Efficiency of neonatal screening for congenital adrenal
نویسنده
چکیده
1 Department of Biostatistics, Groupe hospitalier Cochin Saint Vincent de Paul and University Paris 5 René 8 Descartes, 75014 Paris, France. 9 2 Department of Biochemistry and Molecular Biology, Molecular Endocrinology and Rare Diseases, CBPE, 10 Groupement hospitalier Lyon-Est, Hospices Civils de Lyon, 59 boulevard Pinel 69677 Bron, France 11 3 Association Française pour le Dépistage et la Prévention des Handicaps de l'Enfant, 75015 Paris and Pôle de 12 Pédiatrie, Rennes University Hospital, 35203, France 13 4 Department of Paediatric Endocrinology and Diabetology, INSERM CIC-EC5 and Centre de Référence des 14 Maladies Endocriniennes Rares de la Croissance, Robert Debré Hospital and University Paris 7 Denis Diderot, 15 75019, Paris, France 16 4 A complete list of members of the DHCSF study group is given in appendix. 17 18
منابع مشابه
Pregnanetriolone in paper-borne urine for neonatal screening for 21-hydroxylase deficiency: The place of urine in neonatal screening
The standard method of primary neonatal screening for congenital adrenal hyperlasia (CAH), determination of 17-hydroxyprogesterone (17OHP) in heelprick blood, is the object of recurrent controversy because of its poor diagnostic and economic efficiency. The superior ability of urinary pregnanetriolone levels to discriminate between infants with and without classical CAH has been known for some ...
متن کاملEfficiency of neonatal screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency in children born in mainland France between 1996 and 2003.
OBJECTIVE To assess the efficiency of the French national screening program for 21-hydroxylase deficiency (21-OHD). Neonatal screening for congenital adrenal hyperplasia due to 21-OHD is mainly intended to prevent death due to salt wasting but remains controversial because of the number of false-positive results and the ease with which most female cases can be identified by virilized genitalia ...
متن کاملWeight-adjusted neonatal 17OH-progesterone cutoff levels improve the efficiency of newborn screening for congenital adrenal hyperplasia.
OBJECTIVE To evaluate weight-adjusted strategy for levels of neonatal-17OHP in order to improve newborn screening (NBS) efficiency. SUBJECTS AND METHODS Blood samples collected between 2-7 days of age from 67,640 newborns were evaluated. When N17OHP levels were ≥ 20 ng/mL, and a second sample was requested. We retrospectively analyzed neonatal-17OHP levels measured by Auto DELFIA- B024-112 as...
متن کاملChildren with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor?
BACKGROUND Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screening might later develop signs of androgen excess. The aim of this study is to verify whether a slightly elevated 17-OHP at newborn screening is a predictive factor for premature...
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Neonatal screening for congenital adrenal hyperplasia: experience and results in Argentina. J Pediatr Endocrinol Metab 2008;21:73–8. 19. Cordova RA, Vignola G. Screening and diagnosis of congenital adrenal hyperplasia in Basilicata (Italy). Southeast Asian J Trop Med Pub Health 1999;30: 103–6. 20. Valentino R, Tommaselli AP, Rossi R, et al. A pilot study for neonatal screening of congenital adr...
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